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Multiscale complex Genomics – Exploring the genome beyond sequence
Genomics is probably the fastest evolving field in current science. A decade ago the main concern was to obtain the sequence (1D code) of the genome. Today the big challenges are to determine how genotype information is transferred into phenotype and how pathological phenotypic changes can be predicted from genome alterations. Understanding how the genome is organized in space, and how this affects gene regulation, will be required to fully understand the time-dependent connection between genome and phenome. As technology has advanced, information of the folded state of chromatin has emerged, leading to the advent of a new branch of genomics (3D/4D genomics).
3D/4D genomics represents one of the biggest challenges for biology and biomedicine in the next decade. However, heterogeneity of data, disconnection among databases and lack of standardization in analysis and simulation tools, are threatening to hold back advances in this fast developing field.
MuG responds to the latest computational challenges of 3D/4D genomics by connecting this community to the HPC and Big Data world and providing a suitable set of tools and infrastructure. to integrate the navigation in genomics data from sequence (1D) to 3D/4D chromatin dynamics data.